Assessment of antihyperglycemic and antihyperlipidemic activity of common ayurvedic formulation in alloxan- induced diabetic rabbits

Objective: The present study was planned to evaluate the efficacy of four different ayurvedic formulation for their antihyperglycemic and antihyperlipidemic effect in alloxan induced diabetic rabbits Materials and Methods: Four different ayurvedic formulation (F1,F2,F3,F4)) were administered in different group of alloxan induced diabetic rabbits.Their efficacy, onset and duration of action as antihyperglycemic agents were studied . Their antihyperlipidemic action were also compared. Results: Out of four formulation(F1,F2,F3,F4) studied formulation-F2, showed extremely significant antihyperglycemic activity for satisfactory duration and also showed a significant activity as an antihyperlipidemic agent compared to other three and Tolbutamide. Conclusion: A number of polyherbal formulation are widely marketed claiming to be very effective in diabetes and other associated disease. But, this study indicates that, though there are numerous traditional plants reported to have hypoglycemic properties, many of them proved to be not very effective in lowering blood glucose levels in severe diabetes.